LAPSE:2022.0014
Published Article
LAPSE:2022.0014
Identifying Shared Risk Genes between Nonalcoholic Fatty Liver Disease and Metabolic Traits by Cross-Trait Association Analysis
Hongping Guo, Zuguo Yu
January 24, 2022
Nonalcoholic fatty liver disease (NAFLD) generally co-occurs with metabolic disorders, but it is unclear which genes have a pleiotripic effect on NAFLD and metabolic traits. We performed a large-scale cross-trait association analysis to identify the overlapping genes between NAFLD and nine metabolic traits. Among all the metabolic traits, we found that obesity and type II diabetes are associated with NAFLD. Then, a multitrait association analysis among NAFLD, obesity and type II diabetes was conducted to improve the overall statistical power. We identified 792 significant variants by a cross-trait meta-analysis involving 100 pleiotripic genes. Moreover, we detected another two common genes by a genome-wide gene test. The results from the pathway enrichment analysis show that the 102 shared risk genes are enriched in cancer, diabetes, insulin secretion, and other related pathways. This study can help us understand the molecular mechanisms underlying comorbid NAFLD and metabolic disorders.
Keywords
metabolic trait, nonalcoholic fatty liver disease, shared gene
Subject
Suggested Citation
Guo H, Yu Z. Identifying Shared Risk Genes between Nonalcoholic Fatty Liver Disease and Metabolic Traits by Cross-Trait Association Analysis. (2022). LAPSE:2022.0014
Author Affiliations
Guo H: Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education and Hunan Key Laboratory for Computation and Simulation in Science and Engineering, Xiangtan University, Xiangtan 411105, China; School of Mathematics and Statisti
Yu Z: Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education and Hunan Key Laboratory for Computation and Simulation in Science and Engineering, Xiangtan University, Xiangtan 411105, China; School of Electrical Engineering a [ORCID]
Journal Name
Processes
Volume
9
Issue
1
First Page
pr9010107
Year
2021
Publication Date
2021-01-07
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr9010107, Publication Type: Journal Article
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LAPSE:2022.0014
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doi:10.3390/pr9010107
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Jan 24, 2022
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CC BY 4.0
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[v1] (Original Submission)
Jan 24, 2022
 
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Jan 24, 2022
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https://psecommunity.org/LAPSE:2022.0014
 
Original Submitter
Calvin Tsay
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