LAPSE:2021.0628
Published Article
LAPSE:2021.0628
Shear-Thinning Effect of the Spinning Disc Mixer on Starch Nanoparticle Precipitation
July 19, 2021
Spinning disc technology is capable of achieving intensified micromixing within thin liquid films created through large shear rates, typically of the order of 103 s−1, generated by means of fast disc surface rotation. In this study the effect of the high shear on solvent−antisolvent mixing and starch nanoparticle precipitation is reported. Rheological studies of starch solutions at 2% w/v and 4% w/v have demonstrated their shear-thinning behaviour at the large shear rates experienced on the spinning disc surface. The effect of such high shear rate on starch nanoparticle precipitation is investigated alongside solute concentration and several other operating parameters such as flow rate, disc rotational speed, and solvent/antisolvent ratio. A reduction in nanoparticle size has been observed with an increase in starch concentration, although agglomeration was found to be more prevalent amongst these smaller particles particularly at larger flow rates and disc rotational speeds. Micromixing time, estimated on the basis of an engulfment mechanism, has been correlated against shear rate. With fast micromixing of the order of 1 ms observed at higher shear rates, and which are practically unaffected by the starch concentrations used, micromixing is not thought to be influential in determining the particle characteristics highlighted in this work.
Record ID
Keywords
Process Intensification, shear rate, solvent–antisolvent precipitation, spinning disc, starch nanoparticles, thin films
Subject
Suggested Citation
Sana S, Zivkovic V, Boodhoo K. Shear-Thinning Effect of the Spinning Disc Mixer on Starch Nanoparticle Precipitation. (2021). LAPSE:2021.0628
Author Affiliations
Sana S: School of Engineering, Merz Court, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK
Zivkovic V: School of Engineering, Merz Court, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK
Boodhoo K: School of Engineering, Merz Court, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK [ORCID]
Zivkovic V: School of Engineering, Merz Court, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK
Boodhoo K: School of Engineering, Merz Court, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK [ORCID]
Journal Name
Processes
Volume
8
Issue
12
Article Number
E1622
Year
2020
Publication Date
2020-12-09
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr8121622, Publication Type: Journal Article
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Published Article
LAPSE:2021.0628
This Record
External Link
doi:10.3390/pr8121622
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Version History
[v1] (Original Submission)
Jul 19, 2021
Verified by curator on
Jul 19, 2021
This Version Number
v1
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URL Here
https://psecommunity.org/LAPSE:2021.0628
Original Submitter
Calvin Tsay
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