LAPSE:2021.0481
Published Article
LAPSE:2021.0481
Bactericidal and Virucidal Efficacies and Safety of Puriton®
So-Hyeon Bok, Min-Hee Kim, Soon-Young Lee, Chun-Sik Bae, Min-Jae Lee, Kwang-Ho Kim, Dae-Hun Park
May 27, 2021
In 2016, infectious microbes were one of the leading causes of death, especially in developing countries. Puriton® is a mineral mixture consisting of biotite, kaolinite, montmorillonite, serpentine, clinochlore, and vermiculite, and evaluated antimicrobial activity in vitro and safety in vivo. Nine pathogens and opportunistic bacteria, namely Salmonella typhimurium, Escherichia coli, Pseudomonas aeruginosa, Alcaligenes faecalis, Staphylococcus aureus, Enterococcus faecalis, Micrococcus luteus, Mycobacterium smegmatis, and Bacillus subtilis, and the two viruses Zika and Influenza A/Duck/MN/1525/81 were used. A 26-week oral repeated safety study of Puriton® was conducted. Puriton® suppressed the bacterial proliferation, with a minimum proliferative rate of 91.1% in B. subtilis ATCC6633. The virucidal efficacy of Puriton® against Zika virus after 4 h and 18 h of contact time was significant in all groups treated with Puriton®. Twenty-six-week repeated oral administration of Puriton® was considered safe based on physiological results, such as behavior and blood cells/chemistry, and histopathological changes in the brain, heart, kidney, liver, and lung. We concluded that Puriton® exerted bactericidal and virucidal efficacies and was safe for 26-week repeated oral administration.
Keywords
bactericidal, mineral mixture, Puriton®, safety, virucidal
Subject
Suggested Citation
Bok SH, Kim MH, Lee SY, Bae CS, Lee MJ, Kim KH, Park DH. Bactericidal and Virucidal Efficacies and Safety of Puriton®. (2021). LAPSE:2021.0481
Author Affiliations
Bok SH: College of Korean Medicine, Dongshin University, Naju, Jeonnam 58245, Korea
Kim MH: Department of Forestry, Chonnam National University, Gwangju 61186, Korea
Lee SY: College of Korean Medicine, Dongshin University, Naju, Jeonnam 58245, Korea
Bae CS: College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea
Lee MJ: Department of Veterinary Medicine, Kangwon National University, Gangwon 24341, Korea
Kim KH: Kadesh, Inc., Garden Grove, CA 92841, USA
Park DH: College of Korean Medicine, Dongshin University, Naju, Jeonnam 58245, Korea
Journal Name
Processes
Volume
8
Issue
11
Article Number
E1481
Year
2020
Publication Date
2020-11-17
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr8111481, Publication Type: Journal Article
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LAPSE:2021.0481
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doi:10.3390/pr8111481
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May 27, 2021
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CC BY 4.0
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[v1] (Original Submission)
May 27, 2021
 
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May 27, 2021
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Original Submitter
Calvin Tsay
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