Pharmacological Properties and Chemical Profiles of Passiflora foetida L. Extracts: Novel Insights for Pharmaceuticals and Nutraceuticals

Annalisa Chiavaroli; Simonetta Cristina Di Simone; Kouadio Ibrahime Sinan; Maria Chiara Ciferri; Giancarlo Angeles Flores; Gokhan Zengin; Ouattara Katinan Etienne; Gunes Ak; Mohamad Fawzi Mahomoodally; Sharmeen Jugreet; Zoltán Cziáky; József Jekő; Lucia Recinella; Luigi Brunetti; Sheila Leone; Paola Angelini; Roberto Venanzoni; Luigi Menghini; Claudio Ferrante; Giustino Orlando

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2021.0025

Published Article

LAPSE:2021.0025

Pharmacological Properties and Chemical Profiles of Passiflora foetida L. Extracts: Novel Insights for Pharmaceuticals and Nutraceuticals

Annalisa Chiavaroli, Simonetta Cristina Di Simone, Kouadio Ibrahime Sinan, Maria Chiara Ciferri, Giancarlo Angeles Flores, Gokhan Zengin, Ouattara Katinan Etienne, Gunes Ak, Mohamad Fawzi Mahomoodally, Sharmeen Jugreet, Zoltán Cziáky, József Jekő, Lucia Recinella, Luigi Brunetti, Sheila Leone, Paola Angelini, Roberto Venanzoni, Luigi Menghini, Claudio Ferrante, Giustino Orlando

February 22, 2021

In the present study, Passiflora foetida extracts characterized by different polarities were studied for their phytochemical profile, enzyme inhibitory, and antioxidant potentials. In silico, in vitro and ex vivo studies were also carried out on methanol and water extracts for predicting pharmacokinetics and pharmacodynamics. In this regard, neuronal HypoE22 cells, isolated mouse skin tissues, and pathogen dermatophytes strains were exposed to extracts. Emphasis was given to the preventing effects induced by the extracts on hydrogen peroxide-induced alterations of prostaglandin E2 (PGE2), l-dopa, and serotonin. Chemical analysis revealed the presence of similar compounds in infusion and methanolic extracts. The ex vivo studies also showed protective skin properties by P. foetida water and methanol extracts, as evidenced by the decrease of hydrogen peroxide-induced PGE2 level. Additionally, the blunting effects on hydrogen peroxide-induced l-dopa levels are consistent with the anti-tyrosinase effect exerted by both extracts. In silico studies demonstrated the affinity of extracts’ phytochemicals, namely apigenin, chrysoeriol, loliolide, luteolin, quercetin, and vitexin, towards cyclo-oxygenase-2 and tyrosinase. Finally, microbiological tests demonstrated the efficacy of P. foetida methanol and water extracts as anti-mycotic agents against Trichophyton and Arthroderma species, involved in skin inflammation. Hence, P. foetida L. extracts could represent potential sources of pharmaceuticals and nutraceuticals.

Record ID

LAPSE:2021.0025

Keywords

anti-oxidant/anti-inflammatory effects, bioinformatics/network pharmacology, chemical profile, neuroprotection, Passiflora foetida, skin protection

Subject

Biosystems

Suggested Citation

Chiavaroli A, Di Simone SC, Sinan KI, Ciferri MC, Angeles Flores G, Zengin G, Etienne OK, Ak G, Fawzi Mahomoodally M, Jugreet S, Cziáky Z, Jekő J, Recinella L, Brunetti L, Leone S, Angelini P, Venanzoni R, Menghini L, Ferrante C, Orlando G. Pharmacological Properties and Chemical Profiles of Passiflora foetida L. Extracts: Novel Insights for Pharmaceuticals and Nutraceuticals. (2021). LAPSE:2021.0025

Author Affiliations

Chiavaroli A: Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Di Simone SC: Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Sinan KI: Department of Biology, Faculty of Science, Selcuk University, Campus, Konya 42130, Turkey
Ciferri MC: Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Angeles Flores G: Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy
Zengin G: Department of Biology, Faculty of Science, Selcuk University, Campus, Konya 42130, Turkey [ORCID]
Etienne OK: Laboratoire de Botanique, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan 00225, Cote D’Ivoire
Ak G: Department of Biology, Faculty of Science, Selcuk University, Campus, Konya 42130, Turkey
Fawzi Mahomoodally M: Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam; Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit 230, Mauritius
Jugreet S: Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit 230, Mauritius
Cziáky Z: Agricultural and Molecular Research and Service Institute, University of Nyíregyháza, 4400 Nyíregyháza, Hungary [ORCID]
Jekő J: Agricultural and Molecular Research and Service Institute, University of Nyíregyháza, 4400 Nyíregyháza, Hungary
Recinella L: Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Brunetti L: Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Leone S: Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Angelini P: Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy [ORCID]
Venanzoni R: Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy [ORCID]
Menghini L: Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy [ORCID]
Ferrante C: Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy [ORCID]
Orlando G: Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy

Journal Name

Processes

Volume

8

Issue

9

Article Number

E1034

Year

2020

Publication Date

2020-08-24