LAPSE:2021.0020
Published Article
LAPSE:2021.0020
Screening and Application of Chitin Synthase Inhibitors
February 3, 2021
Chitin is an important part of the fungal cell wall, but is not found in plants and mammals, so chitin synthase (CHS) can be a green fungicide target. In this paper, 35 maleimide compounds were designed and synthesized as CHS inhibitors. All the screened compounds showed different degrees of CHS inhibitory activity and antifungal activity in vitro. In particular, the halfâinhibitory concentration (IC50) value of compound 20 on CHS was 0.12 mM, and the inhibitory effect was better than that of the control polyoxin B (IC50 = 0.19 mM). At the same time, this compound also showed good antifungal activity and has further development value.
Record ID
Keywords
biological activity research, chitin synthase, inhibitors, maleimides
Subject
Suggested Citation
Shi X, Qiu S, Bao Y, Chen H, Lu Y, Chen X. Screening and Application of Chitin Synthase Inhibitors. (2021). LAPSE:2021.0020
Author Affiliations
Shi X: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China [ORCID]
Qiu S: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Bao Y: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Chen H: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Lu Y: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Chen X: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Qiu S: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Bao Y: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Chen H: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Lu Y: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Chen X: College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Journal Name
Processes
Volume
8
Issue
9
Article Number
E1029
Year
2020
Publication Date
2020-08-22
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr8091029, Publication Type: Journal Article
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Published Article
LAPSE:2021.0020
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External Link
doi:10.3390/pr8091029
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Version History
[v1] (Original Submission)
Feb 3, 2021
Verified by curator on
Feb 3, 2021
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v1
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https://psecommunity.org/LAPSE:2021.0020
Original Submitter
Calvin Tsay
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