Numerous organizations are striving to maximize the profit of their businesses by the effective implementation of competitive advantages including cost reduction, quick delivery, and unique high-quality products. Effective production-scheduling techniques are methods that many firms use to attain these competitive advantages. Implementing scheduling techniques in high-mix low-volume (HMLV) manufacturing industries, especially in Industry 4.0 environments, remains a challenge, as the properties of both parts and processes are dynamically changing. As a reaction to these challenges in HMLV Industry 4.0 manufacturing, a newly advanced and effective real-time production-scheduling decision-support system model was developed. The developed model was implemented with the use of robotic process automation (RPA), and it comprises a hybrid of different advanced scheduling techniques obtained as the result of analytical-hierarchy-process (AHP) analysis. The aim of this research was to develop a method to minimize the total production process time (total make span) by considering the results of risk analysis of HMLV manufacturing in Industry 4.0 environments. The new method is the combination of multi-broker (MB) optimization and a genetics algorithm (GA) that uses general key process indicators (KPIs) that are easy to measure in any kind of production. The new MB−GA method is compatible with industry 4.0 environments, so it is easy to implement. Furthermore, MB−GA deals with potential risk during production, so it can provide more accurate results. On the basis of survey results, 16% of the asked companies could easily use the new scheduling method, and 43.2% of the companies could use it after a little modification of production.