Reverse osmosis is the leading process in seawater desalination. However, it is still an energy intensive technology. Feed spacer geometry design is a key factor in reverse osmosis spiral wound membrane module performance. Correlations obtained from experimental work and computational fluid dynamics modeling were used in a computational tool to simulate the impact of different feed spacer geometries in seawater reverse osmosis spiral wound membrane modules with different permeability coefficients in pressure vessels with 6, 7 and 8 elements. The aim of this work was to carry out a comparative analysis of the effect of different feed spacer geometries in combination with the water and solute permeability coefficients on seawater reverse osmosis spiral wound membrane modules performance. The results showed a higher impact of feed spacer geometries in the membrane with the highest production (highest water permeability coefficient). It was also found that the impact of feed spacer geometry increased with the number of spiral wound membrane modules in series in the pressure vessel. Installation of different feed spacer geometries in reverse osmosis membranes depending on the operating conditions could improve the performance of seawater reverse osmosis systems in terms of energy consumption and permeate quality.