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Records Added in August 2019
Records added in August 2019
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Showing records 76 to 77 of 77. [First] Page: 1 2 3 4 Last
Dynamic Modelling and Optimisation of the Batch Enzymatic Synthesis of Amoxicillin
Andrew B. Cuthbertson, Alistair D. Rodman, Samir Diab, Dimitrios I. Gerogiorgis
August 5, 2019 (v1)
Keywords: Amoxicillin, dynamic optimisation, enzymatic synthesis, non-isothermal modelling, parameter estimation
Amoxicillin belongs to the β-lactam family of antibiotics, a class of highly consumed pharmaceutical products used for the treatment of respiratory and urinary tract infections, and is listed as a World Health Organisation (WHO) “Essential Medicine”. The demonstrated batch enzymatic synthesis of amoxicillin is composed of a desired synthesis and two undesired hydrolysis reactions of the main substrate (6-aminopenicillanic acid (6-APA)) and amoxicillin. Dynamic simulation and optimisation can be used to establish optimal control policies to attain target product specification objectives for bioprocesses. This work performed dynamic modelling, simulation and optimisation of the batch enzymatic synthesis of amoxicillin. First, kinetic parameter regression at different operating temperatures was performed, followed by Arrhenius parameter estimation to allow for non-isothermal modelling of the reaction network. Dynamic simulations were implemented to understand the behaviour of the design s... [more]
Model-Based Design and Process Optimization of Continuous Single Pass Tangential Flow Filtration Focusing on Continuous Bioprocessing
Maximilian J. Huter, Jochen Strube
August 5, 2019 (v1)
Keywords: Continuous Bioprocessing (CBP), Conceptual Process Design (CPD), Single-Pass-Tangential-Flow-Filtration (SPTFF), modelling, ultrafiltration
In this study the Single-Pass-Tangential-Flow-Filtration (SPTFF) concept for continuous ultrafiltration in bioprocessing is investigated. Based on a previously validated physico-chemical model for a single ultrafiltration cassette, the transfer to a multistage SPTFF is predicted and validated experimentally by concentration steps for bovine serum albumin (BSA) and the monoclonal antibody immunoglobulin G (IgG) are compared. The model applied for the ultrafiltration membrane contains the Stagnant Film Model (SFM) for concentration polarization, as well as the Osmotic Pressure Model (OPM) and the Boundary Layer Model (BLM) for the mass transfer through the membrane. In addition, pressure drop correlations as a function of the Reynolds number are included to describe the development of the transmembrane pressure over the length of the module. The outcome of this study shows the potential to improve this multi-parameter dependent unit operation by a model-based optimization allowing signif... [more]
Showing records 76 to 77 of 77. [First] Page: 1 2 3 4 Last
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