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Records with Keyword: Polymers
Impact of Hot-Melt-Extrusion on Solid-State Properties of Pharmaceutical Polymers and Classification Using Hierarchical Cluster Analysis
Ioannis Partheniadis, Miltiadis Toskas, Filippos-Michail Stavras, Georgios Menexes, Ioannis Nikolakakis
April 16, 2021 (v1)
Keywords: classification, dendrograms, factor analysis, hot-melt extrusion, Polymers, powders
The impact of hot-melt extrusion (HME) on the solid-state properties of four methacrylic (Eudragit® L100-55, Eudragit® EPO, Eudragit® RSPO, Eudragit® RLPO) and four polyvinyl (Kollidon® VA64, Kollicoat® IR, Kollidon® SR, and Soluplus®) polymers was studied. Overall, HME decreased Tg but increased electrostatic charge and surface free energy. Packing density decreased with electrostatic charge, whereas Carr’s and Hausner indices showed a peak curve dependency. Overall, HME reduced work of compaction (Wc), deformability (expressed as Heckel PY and Kawakita 1/b model parameters and as slope S′ of derivative force/displacement curve), and tablet strength (TS) but increased elastic recovery (ER). TS showed a better correlation with S′ than PY and 1/b. Principal component analysis (PCA) organized the data of neat and extruded polymers into three principal components explaining 72.45% of the variance. The first included Wc, S′ and TS with positive loadings expressing compaction, and ER with n... [more]
Comparison of a Novel Miniaturized Screening Device with Büchi B290 Mini Spray-Dryer for the Development of Spray-Dried Solid Dispersions (SDSDs)
Aymeric Ousset, Joke Meeus, Florent Robin, Martin Alexander Schubert, Pascal Somville, Kalliopi Dodou
August 28, 2018 (v1)
Keywords: amorphous solid dispersions, downscaling, miniaturization, miscibility, Polymers, screening, spray-dryer
Spray-drying is an increasingly popular technology for the production of amorphous solid dispersions (ASDs) in the pharmaceutical industry that is used in the early evaluation and industrial production of formulations. Efficient screening of ASD in the earliest phase of drug development is therefore critical. A novel miniaturized atomization equipment for screening spray-dried solid dispersions (SDSDs) in early formulation and process development was developed. An in-depth comparison between the equipment/process parameters and performance of our novel screening device and a laboratory Büchi B290 mini spray-dryer was performed. Equipment qualification was conducted by comparing the particle/powder attributes, i.e., miscibility/solid state, residual solvent, and morphological properties of binary SDSDs of itraconazole prepared at both screening and laboratory scales. The operating mode of the miniaturized device was able to reproduce similar process conditions/parameters (e.g., outlet t... [more]
Solving Materials’ Small Data Problem with Dynamic Experimental Databases
Michael McBride, Nils Persson, Elsa Reichmanis, Martha A. Grover
July 31, 2018 (v1)
Keywords: classification, database, informatics, materials, Polymers, processing
Materials processing is challenging because the final structure and properties often depend on the process conditions as well as the composition. Past research reported in the archival literature provides a valuable source of information for designing a process to optimize material properties. Typically, the issue is not having too much data (i.e., big data), but rather having a limited amount of data that is sparse, relative to a large number of design variables. The full utilization of this information via a structured database can be challenging, because of inconsistent and incorrect reporting of information. Here, we present a classification approach specifically tailored to the task of identifying a promising design region from a literature database. This design region includes all high performing points, as well as some points having poor performance, for the purpose of focusing future experiments. The classification method is demonstrated on two case studies in polymeric materia... [more]
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