Proceedings of ESCAPE 35ISSN: 2818-4734
Volume: 4 (2025)
Table of Contents
LAPSE:2025.0560
Published Article
LAPSE:2025.0560
Data-driven Modeling of a Continuous Direct Compression Tableting Process using SINDy
Pau Lapiedra Carrasquer, Satyajeet S. Bhonsale, Carlos André Muñoz López, Kristof Dockx, Jan F.M. Van Impe
June 27, 2025
Abstract
Understanding the complex dynamics of continuous processes in pharmaceutical manufacturing is essential to ensure product quality across the production line. This paper presents a data-driven modeling approach using Sparse Identification of Nonlinear Dynamics with Control (SINDYc) to capture the dynamics of a continuous direct compression (CDC) tableting line. By incorporating delayed control inputs into the candidate function library, the model effectively captures deviations from steady state in response to dynamic changes. The proposed model was developed by finding a balance between accuracy and sparsity, with focus on the ability to generalize to a wide range of operating conditions.
Keywords
Suggested Citation
Carrasquer PL, Bhonsale SS, López CAM, Dockx K, Impe JFV. Data-driven Modeling of a Continuous Direct Compression Tableting Process using SINDy. Systems and Control Transactions 4:2542-2547 (2025) https://doi.org/10.69997/sct.147925
Author Affiliations
Carrasquer PL: BioTeC+, KU Leuven, Gebroeders De Smetstraat 1, Gent 9000, Belgium; Janssen Pharmaceutica NV, a Johnson & Johnson company, Turnhoutseweg 30, 2340 Beerse, Belgium
Bhonsale SS: BioTeC+, KU Leuven, Gebroeders De Smetstraat 1, Gent 9000, Belgium
López CAM: Janssen Pharmaceutica NV, a Johnson & Johnson company, Turnhoutseweg 30, 2340 Beerse, Belgium
Dockx K: Janssen Pharmaceutica NV, a Johnson & Johnson company, Turnhoutseweg 30, 2340 Beerse, Belgium
Impe JFV: BioTeC+, KU Leuven, Gebroeders De Smetstraat 1, Gent 9000, Belgium
Journal Name
Systems and Control Transactions
Volume
4
First Page
2542
Last Page
2547
Year
2025
Publication Date
2025-07-01
Version Comments
Original Submission
Other Meta
PII: 2542-2547-1376-SCT-4-2025, Publication Type: Journal Article
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LAPSE:2025.0560
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https://doi.org/10.69997/sct.147925
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Jun 27, 2025
 
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References Cited
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