LAPSE:2021.0740
Published Article
LAPSE:2021.0740
Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro
September 22, 2021
Defined by its potential for self-renewal, differentiation and tumorigenicity, cancer stem cells (CSCs) are considered responsible for drug resistance and relapse. To understand the behavior of CSC, the effects of the microenvironment in each tissue are a matter of great concerns for scientists in cancer biology. However, there are many complicated obstacles in the mimicking the microenvironment of CSCs even with current advanced technology. In this context, novel biomaterials have widely been assessed as in vitro platforms for their ability to mimic cancer microenvironment. These efforts should be successful to identify and characterize various CSCs specific in each type of cancer. Therefore, extracellular matrix scaffolds made of biomaterial will modulate the interactions and facilitate the investigation of CSC associated with biological phenomena simplifying the complexity of the microenvironment. In this review, we summarize latest advances in biomaterial scaffolds, which are exploited to mimic CSC microenvironment, and their chemical and biological requirements with discussion. The discussion includes the possible effects on both cells in tumors and microenvironment to propose what the critical factors are in controlling the CSC microenvironment focusing the future investigation. Our insights on their availability in drug screening will also follow the discussion.
Keywords
biomaterial scaffolds, cancer stem cells, drug screening, tumor microenvironment
Subject
Suggested Citation
Hassan G, Afify SM, Kitano S, Seno A, Ishii H, Shang Y, Matsusaki M, Seno M. Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro. (2021). LAPSE:2021.0740
Author Affiliations
Hassan G: Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan; Department of Microbiology and Biochemistry, Faculty of Pharmacy, Damascus University, Damascus 10769, Syria [ORCID]
Afify SM: Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan; Division of Biochemistry, Chemistry Department, Faculty of Science, Menoufia University, Shebin El Koum 32511, Egypt [ORCID]
Kitano S: Technical Research Institute, Toppan Printing Co., Ltd., 4-2-3 Takanodaiminami, Sugito-Machi, Saitama 345-8508, Japan [ORCID]
Seno A: Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan [ORCID]
Ishii H: GSP Enterprise, Inc., 1-4-38 12F Minato-Machi, Naniwaku, Osaka 556-0017, Japan [ORCID]
Shang Y: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita Osaka 565-0871, Japan
Matsusaki M: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita Osaka 565-0871, Japan [ORCID]
Seno M: Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan [ORCID]
Journal Name
Processes
Volume
9
Issue
1
First Page
pr9010045
Year
2020
Publication Date
2020-12-28
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr9010045, Publication Type: Review
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LAPSE:2021.0740
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doi:10.3390/pr9010045
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Sep 22, 2021
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CC BY 4.0
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[v1] (Original Submission)
Sep 22, 2021
 
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Sep 22, 2021
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Original Submitter
Calvin Tsay
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