LAPSE:2021.0682
Published Article
LAPSE:2021.0682
Pharmacoeconomic Analysis of Hemophilia Care in Romania
Petre Serban, Brigitha Vlaicu, Margit Serban, Cristina Emilia Ursu, Adina Traila, Cristian Jinca, Jenel Marian Patrascu, Daniel Andrei, Andrei Kozma, Teodora Smaranda Arghirescu
July 29, 2021
Hemophilia, a congenital X linked disease, has the serious burden of bleeding, requiring life-long replacement with coagulation factors (CF). In the present day, there is a continuously improving treatment for this condition. Objective: Our observational, cross-sectional study aims at finding out whether a prophylactic replacement with CF is affordable from the point of view of its cost-effectiveness in our country. Material and methods: A cohort of 122 persons with hemophilia were included in this patient-reported outcome survey, and they answered a questionnaire consisting of 56 items, focused on 4 domains—socio-demographic, medical, quality of health/life and cost/cost-effectiveness. Results and discussion: The markers for quality of health/life were correlated with the direct and indirect costs of care, comparing subgroup 1 of patients with prophylactic vs. subgroup 2 with on-demand replacement. Based on the incremental quality adjusted life years and the incremental costs, we calculated the incremental cost-effectiveness ratio (ICER) proving that prophylaxis is more cost-effective than on-demand replacement on a long time basis. Conclusions: The ICER is a threshold recommending the reimbursement of costs for a life-long prophylactic replacement in our country.
Keywords
hemophilia, ICER, socio-economic burden
Subject
Suggested Citation
Serban P, Vlaicu B, Serban M, Ursu CE, Traila A, Jinca C, Patrascu JM, Andrei D, Kozma A, Arghirescu TS. Pharmacoeconomic Analysis of Hemophilia Care in Romania. (2021). LAPSE:2021.0682
Author Affiliations
Serban P: Department 14, Center for Preventive Medicine Studies, Victor Babes University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
Vlaicu B: Department 14, Center for Preventive Medicine Studies, Victor Babes University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
Serban M: Romanian Academy of Medical Sciences, Onco-Hematology Research Unit, Children Emergency Hospital “Louis Turcanu” Timisoara, European Hemophilia Treatment Centre, 300011 Timisoara, Romania
Ursu CE: Romanian Academy of Medical Sciences, Onco-Hematology Research Unit, Children Emergency Hospital “Louis Turcanu” Timisoara, European Hemophilia Treatment Centre, 300011 Timisoara, Romania [ORCID]
Traila A: Medical Centre for Evaluation Therapy, Medical Education and Rehabilitation of Children and Young Adults, European Hemophilia Treatment Centre, 305100 Buzias, Romania
Jinca C: Department of Pediatrics, Division of Onco-Hematology, Victor Babes University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
Patrascu JM: Department of Orthopedics, Victor Babes University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
Andrei D: Romanian Hemophilia Association, 300011 Timisoara, Romania
Kozma A: Research Department in Social Paediatrics and Obstetrics, “Alessandrescu-Rusescu”, National Institute for Mother and Child Health, 020395 Bucharest, Romania
Arghirescu TS: Department of Pediatrics, Division of Onco-Hematology, Victor Babes University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania
Journal Name
Processes
Volume
8
Issue
12
Article Number
E1676
Year
2020
Publication Date
2020-12-18
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr8121676, Publication Type: Journal Article
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LAPSE:2021.0682
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doi:10.3390/pr8121676
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Jul 29, 2021
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CC BY 4.0
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Jul 29, 2021
 
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Original Submitter
Calvin Tsay
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