With the growing demand of supercritical carbon dioxide (SC-CO2) dyeing, it is important to precisely predict the dyeing effect of supercritical carbon dioxide. In this work, Generalized Regression Neural Network (GRNN) and Back Propagation Neural Network (BPNN) models have been employed to predict the dyeing effect of SC-CO2. These two models have been constructed based on published experimental data and calculated values. A total of 386 experimental data sets were used in the present work. In GRNN and BPNN models, two input parameters, such as temperature, pressure, dye stuff types, carrier types and dyeing time, were selected for the input layer and one variable, K/S value or dye-uptake, was used in the output layer. It was found that the values of mean-relative-error (MRE) for BPNN model and for GRNN model are 3.27−6.54% and 1.68−3.32%, respectively. The results demonstrate that both BPNN and GPNN models can accurately predict the effect of supercritical dyeing but the former is better than the latter.