The study aimed to theoretically substantiate the efficiency of liquid purification and obtain corroborating experimental data for a hydrocyclone, consisting of several blocks. Mathematical models of the process of hydrodynamic fluid filtration were developed with the use of screw swirlers. The obtained mathematical models characterize all the main processes of fluid movement in various zones of the functioning of the hydrocyclone. Formulas for calculating the structures of hydrocyclone blocks are included. A block for swirling the flow of the liquid to be cleaned has been made in the form of a three-way screw. For the first time, wear-resistant and high-strength plastic ZEDEX ZX-324 has been used as a material. An experimental study was conducted and the change in the Reynolds number and the coefficient of fluid consumption was shown, using different constructions of the three-way screw. The research results confirmed the correctness and sufficiency of mathematical models for the development and production of block hydrocyclones.