LAPSE:2021.0573
Published Article
LAPSE:2021.0573
Design of a Separation Process for Natural 2-Phenylethanol with Economic and Safety Considerations
Luis E. Puga-Córdova, Zahira A. Pérez-Sánchez, Antíoco López-Molina, Laura Conde-Báez, Arturo Jiménez-Gutiérrez, Carolina Conde-Mejía
June 29, 2021
The present work aimed to design a separation process for 2-phenylethanol (2-PEA) produced by whey fermentation and to evaluate its economic potential. The separation sequence consisted of a liquid−liquid extraction column followed by two distillation columns for 2-PEA purification and solvent recovery. In addition, the use of ethyl acetate as a solvent for the extraction process was analyzed. The results, aided by the Aspen Plus v.10 process simulator, showed that 2-PEA can be separated with a purity of 96% by weight. The operating cost of the process, estimated at USD 22.70 per kilogram, shows that the separation alternative developed in this work has a high economic potential. The use of ethyl acetate as a solvent was found to efficiently remove 2-PEA from the fermentation mixture. From a process safety analysis point of view, the use of a bioprocess safety index developed in this work identified the separation process sections that could require special attention as part of the safety engineering stage of the process implementation.
Keywords
bioprocess stream index, natural 2-phenylethanol, safety assessment, separation process design, whey fermentation
Suggested Citation
Puga-Córdova LE, Pérez-Sánchez ZA, López-Molina A, Conde-Báez L, Jiménez-Gutiérrez A, Conde-Mejía C. Design of a Separation Process for Natural 2-Phenylethanol with Economic and Safety Considerations. (2021). LAPSE:2021.0573
Author Affiliations
Puga-Córdova LE: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Carretera Estatal Libre Villahermosa—Comalcalco Km 27 s/n, Ranchería Ribera Alta, Jalpa de Méndez 86205, Tabasco, Mexico
Pérez-Sánchez ZA: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Carretera Estatal Libre Villahermosa—Comalcalco Km 27 s/n, Ranchería Ribera Alta, Jalpa de Méndez 86205, Tabasco, Mexico
López-Molina A: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Carretera Estatal Libre Villahermosa—Comalcalco Km 27 s/n, Ranchería Ribera Alta, Jalpa de Méndez 86205, Tabasco, Mexico [ORCID]
Conde-Báez L: Ingeniería en Biotecnología, Universidad Politécnica de Pachuca, Carretera Ciudad Sahagún-Pachuca Km 20, Ex-Hacienda de Santa Bárbara, Zempoala 43830, Hidalgo, Mexico
Jiménez-Gutiérrez A: Instituto Tecnológico de Celaya, Tecnológico Nacional de México, García Cubas Pte 600 esq, Avenida Tecnológico, Celaya 38010, Guanajuato, Mexico
Conde-Mejía C: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Carretera Estatal Libre Villahermosa—Comalcalco Km 27 s/n, Ranchería Ribera Alta, Jalpa de Méndez 86205, Tabasco, Mexico [ORCID]
Journal Name
Processes
Volume
8
Issue
12
Article Number
E1570
Year
2020
Publication Date
2020-11-28
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr8121570, Publication Type: Journal Article
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LAPSE:2021.0573
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doi:10.3390/pr8121570
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Jun 29, 2021
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Jun 29, 2021
 
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Calvin Tsay
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