LAPSE:2021.0294
Published Article
LAPSE:2021.0294
Mathematical Modeling of Hydrodynamics in Bioreactor by Means of CFD-Based Compartment Model
Agnieszka Krychowska, Marian Kordas, Maciej Konopacki, Bartłomiej Grygorcewicz, Daniel Musik, Krzysztof Wójcik, Magdalena Jędrzejczak-Silicka, Rafał Rakoczy
April 29, 2021
This study presents the procedure of deriving a compartmental model (CM) based on an analysis obtained from the computational fluid dynamics (CFD) model of a bioreactor. The CM is composed of two parts, a structural (that takes into account the architecture of the mathematical model), and a parametric part (which contains the extrinsic parameters of the model). The CM is composed of the branches containing the set of perfectly mixed continuous stirred-tank reactors (CSTRs) in a configuration that matches the bioreactor’s flow patterns. Therefore, this work’s main objective was to develop a mathematical model that incorporated the flow field obtained by CFD technique. The proposed mathematical model was validated by means of the experimental data in the form of the residence time distribution (RTD) measurements.
Keywords
biochemical engineering, bioreactors, mathematical modeling, Modelling
Suggested Citation
Krychowska A, Kordas M, Konopacki M, Grygorcewicz B, Musik D, Wójcik K, Jędrzejczak-Silicka M, Rakoczy R. Mathematical Modeling of Hydrodynamics in Bioreactor by Means of CFD-Based Compartment Model. (2021). LAPSE:2021.0294
Author Affiliations
Krychowska A: Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Avenue 42, 71-065 Szczecin, Poland
Kordas M: Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Avenue 42, 71-065 Szczecin, Poland
Konopacki M: Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Avenue 42, 71-065 Szczecin, Poland [ORCID]
Grygorcewicz B: Department of Laboratory Medicine, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland [ORCID]
Musik D: Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Avenue 42, 71-065 Szczecin, Poland; ESC Global Sp. z o.o., Słoneczny Sad 4F, 72-002 Dołuje, Poland
Wójcik K: Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Avenue 42, 71-065 Szczecin, Poland; ESC Global Sp. z o.o., Słoneczny Sad 4F, 72-002 Dołuje, Poland
Jędrzejczak-Silicka M: Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin, Janickiego Street 32, 71-270 Szczecin, Poland [ORCID]
Rakoczy R: Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Avenue 42, 71-065 Szczecin, Poland [ORCID]
Journal Name
Processes
Volume
8
Issue
10
Article Number
E1301
Year
2020
Publication Date
2020-10-16
Published Version
ISSN
2227-9717
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PII: pr8101301, Publication Type: Journal Article
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LAPSE:2021.0294
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doi:10.3390/pr8101301
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Apr 29, 2021
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Original Submitter
Calvin Tsay
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