Carbon capture and utilization (CCU) may offer a response to climate change mitigation from major industrial emitters. CCU can turn waste CO2 emissions into valuable products such as chemicals and fuels. Consequently, attention has been paid to petrochemical industries as one of the best options for CCU. The largest industrial CO2 removal monoethanol amine-based plant in Iran has been simulated with the aid of a chemical process simulator, i.e., Aspen HYSYS® v.10. The thermodynamic properties are calculated with the acid gas property package models, which are available in Aspen HYSYS®. The results of simulation are validated by the actual data provided by Kermanshah Petrochemical Industries Co. Results show that there is a good agreement between simulated results and real performance of the plant under different operational conditions. The main parameters such as capture efficiency in percent, the heat consumption in MJ/kg CO2 removed, and the working capacity of the plant are calculated as a function of inlet pressure and temperature of absorber column. The best case occurred at the approximate temperature of 40 to 42 °C and atmospheric pressure with CO2 removal of 80.8 to 81.2%; working capacity of 0.232 to 0.233; and heat consumption of 4.78 MJ/kg CO2.