In this paper, we propose a novel clustering approach based on P systems and grid- density strategy. We present grid-density based approach for clustering high dimensional data, which first projects the data patterns on a two-dimensional space to overcome the curse of dimensionality problem. Then, through meshing the plane with grid lines and deleting sparse grids, clusters are found out. In particular, we present weighted spiking neural P systems with anti-spikes and astrocyte (WSNPA2 in short) to implement grid-density based approach in parallel. Each neuron in weighted SN P system contains a spike, which can be expressed by a computable real number. Spikes and anti-spikes are inspired by neurons communicating through excitatory and inhibitory impulses. Astrocytes have excitatory and inhibitory influence on synapses. Experimental results on multiple real-world datasets demonstrate the effectiveness and efficiency of our approach.