The influence of low-pressure environment on centrifugal fan’s flow and noise characteristics was studied experimentally and numerically. A testbed was established to conduct the experimental test on the performance of a centrifugal fan, and the characteristic curve and power consumption curve of the fan under different pressure were obtained. Then the simulation model of the centrifugal fan was established, which was used to simulate the working process of centrifugal fan under different negative pressures. The results showed that the total pressure and static pressure of the fan decrease with the decrease of the ambient pressure. The total and static pressures of the fan under 60 kPa pressure condition decreased by 42.3% and 38.3%, respectively, compared with those of fan under the normal pressure. The main reason for this phenomenon is that the decrease of the environmental pressure leads to the decrease of air density. Besides, with the drop of environmental pressure, the sound pressure and sound power of the fan noise decreases.