LAPSE:2020.1078
Published Article
LAPSE:2020.1078
Reckoning the Dearth of Bioinformatics in the Arena of Diabetic Nephropathy (DN)—Need to Improvise
Jae-Wook Oh, Manikandan Muthu, Steve W. Haga, Vimala Anthonydhason, Piby Paul, Sechul Chun
October 26, 2020
Diabetic nephropathy (DN) is a recent rising concern amongst diabetics and diabetologist. Characterized by abnormal renal function and ending in total loss of kidney function, this is becoming a lurking danger for the ever increasing population of diabetics. This review touches upon the intensity of this complication and briefly reviews the role of bioinformatics in the area of diabetes. The advances made in the area of DN using proteomic approaches are presented. Compared to the enumerable inputs observed through the use of bioinformatics resources in the area of proteomics and even diabetes, the existing scenario of skeletal application of bioinformatics advances to DN is highlighted and the reasons behind this discussed. As this review highlights, almost none of the well-established tools that have brought breakthroughs in proteomic research have been applied into DN. Laborious, voluminous, cost expensive and time-consuming methodologies and advances in diagnostics and biomarker discovery promised through beckoning bioinformatics mechanistic approaches to improvise DN research and achieve breakthroughs. This review is expected to sensitize the researchers to fill in this gap, exploiting the available inputs from bioinformatics resources.
Keywords
bioinformatics, diabetes, diabetic nephropathy, microalbumin, proteomics
Suggested Citation
Oh JW, Muthu M, Haga SW, Anthonydhason V, Paul P, Chun S. Reckoning the Dearth of Bioinformatics in the Arena of Diabetic Nephropathy (DN)—Need to Improvise. (2020). LAPSE:2020.1078
Author Affiliations
Oh JW: Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 143-701, Korea [ORCID]
Muthu M: Department of Environmental Health Sciences, Konkuk University, Seoul 143-701, Korea
Haga SW: Department of Computer Science and Engineering, National Sun Yat Sen University, Kaohsiung 804, Taiwan
Anthonydhason V: Department of Microbiology and Immunology, Institute for Biomedicine, Gothenburg University, 413-90 Goteborg, Sweden
Paul P: St. Jude Children’s Cancer Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
Chun S: Department of Environmental Health Sciences, Konkuk University, Seoul 143-701, Korea [ORCID]
Journal Name
Processes
Volume
8
Issue
7
Article Number
E808
Year
2020
Publication Date
2020-07-09
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr8070808, Publication Type: Review
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LAPSE:2020.1078
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doi:10.3390/pr8070808
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Oct 26, 2020
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CC BY 4.0
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Oct 26, 2020
 
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Calvin Tsay
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