LAPSE:2020.1058
Published Article
LAPSE:2020.1058
Spray Drying for the Preparation of Nanoparticle-Based Drug Formulations as Dry Powders for Inhalation
October 26, 2020
Nanoparticle-based therapeutics have been used in pulmonary formulations to enhance delivery of poorly water-soluble drugs, protect drugs against degradation and achieve modified release and drug targeting. This review focuses on the use of spray drying as a solidification technique to produce microparticles containing nanoparticles (i.e., nanoparticle (NP) agglomerates) with suitable properties as dry powders for inhalation. The review covers the general aspects of pulmonary drug delivery with emphasis on nanoparticle-based dry powders for inhalation and the principles of spray drying as a method for the conversion of nanosuspensions to microparticles. The production and therapeutic applications of the following types of NP agglomerates are presented: nanoporous microparticles, nanocrystalline agglomerates, lipid-based and polymeric formulations. The use of alternative spray-drying techniques, namely nano spray drying, and supercritical CO2-assisted spray drying is also discussed as a way to produce inhalable NP agglomerates.
Record ID
Keywords
drug nanoparticles, dry powder inhalers, nanoparticle agglomerates, pulmonary drug delivery, spray drying
Subject
Suggested Citation
Malamatari M, Charisi A, Malamataris S, Kachrimanis K, Nikolakakis I. Spray Drying for the Preparation of Nanoparticle-Based Drug Formulations as Dry Powders for Inhalation. (2020). LAPSE:2020.1058
Author Affiliations
Malamatari M: Department of Pharmaceutics, UCL School of Pharmacy, 29−39 Brunswick Square, London WC1N 1AX, UK [ORCID]
Charisi A: Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Malamataris S: Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Kachrimanis K: Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece [ORCID]
Nikolakakis I: Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece [ORCID]
Charisi A: Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Malamataris S: Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Kachrimanis K: Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece [ORCID]
Nikolakakis I: Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece [ORCID]
Journal Name
Processes
Volume
8
Issue
7
Article Number
E788
Year
2020
Publication Date
2020-07-06
Published Version
ISSN
2227-9717
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Original Submission
Other Meta
PII: pr8070788, Publication Type: Review
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Published Article
LAPSE:2020.1058
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External Link
doi:10.3390/pr8070788
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Version History
[v1] (Original Submission)
Oct 26, 2020
Verified by curator on
Oct 26, 2020
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v1
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https://psecommunity.org/LAPSE:2020.1058
Original Submitter
Calvin Tsay
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