LAPSE:2020.0792
Published Article
LAPSE:2020.0792
Pollen Bee Aqueous Extract-Based Synthesis of Silver Nanoparticles and Evaluation of Their Anti-Cancer and Anti-Bacterial Activities
July 2, 2020
Bee pollens are rich source of essential amino acids and are often considered as complete food for human beings. Herein, we exploited the potential reducing abilities of Bee pollens extract for the eco-friendly preparation of silver nanoparticles (AgNPs-G). The resulting NPs were characterized using a combination of microscopic and spectroscopic techniques. The analyses confirm the formation of spherical Ag NPs. AgNPs-G obtained from the aqueous extract of bee pollens was used to study their antibacterial properties against Gram-positive and Gram-negative microbes using the Minimum Inhibitory Concentration 50 (MIC50) method. The antibacterial properties of AgNPs-G were compared to the properties of chemically synthesized Ag NPs (AgNPs-C) using sodium borohydride as a reducing agent. The green synthesized nanoparticles (AgNPs-G) exhibited a better antibacterial activity against most of the studied strains when compared to the chemically synthesized Ag NPs (AgNPs-C). In addition, the anti-cancer activity of Ag NPs was also studied against human liver and breast carcinoma cell lines by applying MTT-assay. The Ag NPs demonstrated considerable anticancer activity against the studied cell lines and exhibited high IC50 values in both MCF-7 and HepG2 cell lines.
Record ID
Keywords
anti-bacterial, anti-cancer, bee pollen aqueous extract, eco-friendly, silver nanoparticles
Subject
Suggested Citation
Al-Yousef HM, Amina M, Alqahtani AS, Alqahtani MS, Malik A, Hatshan MR, Siddiqui MRH, Khan M, Shaik MR, Ola MS, Syed R. Pollen Bee Aqueous Extract-Based Synthesis of Silver Nanoparticles and Evaluation of Their Anti-Cancer and Anti-Bacterial Activities. (2020). LAPSE:2020.0792
Author Affiliations
Al-Yousef HM: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia [ORCID]
Amina M: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Alqahtani AS: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia [ORCID]
Alqahtani MS: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia; Nanomedicine Research Unit, Department of Pharmaceutics, King Saud University, Riyadh 11451, Saudi Arabia [ORCID]
Malik A: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia; Nanomedicine Research Unit, Department of Pharmaceutics, King Saud University, Riyadh 11451, Saudi Arabia
Hatshan MR: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Siddiqui MRH: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia [ORCID]
Khan M: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia [ORCID]
Shaik MR: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia [ORCID]
Ola MS: Department of Biochemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia [ORCID]
Syed R: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia; Nanomedicine Research Unit, Department of Pharmaceutics, King Saud University, Riyadh 11451, Saudi Arabia
Amina M: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Alqahtani AS: Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia [ORCID]
Alqahtani MS: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia; Nanomedicine Research Unit, Department of Pharmaceutics, King Saud University, Riyadh 11451, Saudi Arabia [ORCID]
Malik A: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia; Nanomedicine Research Unit, Department of Pharmaceutics, King Saud University, Riyadh 11451, Saudi Arabia
Hatshan MR: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Siddiqui MRH: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia [ORCID]
Khan M: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia [ORCID]
Shaik MR: Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia [ORCID]
Ola MS: Department of Biochemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia [ORCID]
Syed R: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia; Nanomedicine Research Unit, Department of Pharmaceutics, King Saud University, Riyadh 11451, Saudi Arabia
Journal Name
Processes
Volume
8
Issue
5
Article Number
E524
Year
2020
Publication Date
2020-04-29
Published Version
ISSN
2227-9717
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Original Submission
Other Meta
PII: pr8050524, Publication Type: Journal Article
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LAPSE:2020.0792
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doi:10.3390/pr8050524
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[v1] (Original Submission)
Jul 2, 2020
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Jul 2, 2020
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https://psecommunity.org/LAPSE:2020.0792
Original Submitter
Calvin Tsay
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