LAPSE:2020.0317
Published Article
LAPSE:2020.0317
Optimization of Microwave-Assisted Extraction Process of Callicarpa candicans (Burm. f.) Hochr Essential Oil and Its Inhibitory Properties against Some Bacteria and Cancer Cell Lines
April 1, 2020
Callicarpa candicans (Burm. f.) Hochr. (Callicarpa cana L.) is a medicinal plant that is distributed mainly in the tropics and subtropics of Asia and finds a wide range of uses in traditional medicine. In this study, we attempted and optimized the microwave-assisted hydro-distillation (MAHD) process to obtain essential oil from the leaves of C. candicans. In addition, the obtained oil was analyzed for volatile composition by gas chromatography−mass spectrometry (GC-MS) and assayed for bioactivity against several bacteria and cancer cell lines. To optimize the extraction process, response surface methodology (RSM) in combination with central composite design (CCD) was adopted. Experimental design and optimization were carried out with respect to three experimental factors including the ratio of water to raw material, extraction time, and microwave power. The optimal extraction conditions were obtained as follows: water to raw material ratio of 6/1 (v/w), extraction time 42 min, and microwave power 440 W. Composition determination of the obtained C. candicans essential oil indicated the presence of predominant components including caryophyllene (10.45%), cadinene (10.28%), gurjunene (8.95%), muurolene (8.92%), selinene (7.06%), selinene (5.59%), and copaene (5.40%). In comparison with the essential oils obtained via traditional hydro-distillation method, the essential oil extracted by MAHD exhibited superior anti-proliferative activity on all tested cancer cell lines. Current results imply that the MAHD is capable of recovering biologically-active natural products of greater quantity than that recovered by the conventional distillation.
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Keywords
anti-proliferative activity, antimicrobial activities, Callicarpa candicans, essential oil, microwave-assisted extraction, Optimization, response surface methodology, the MAHD
Subject
Suggested Citation
Tran QT, Vu Thi TL, Do TL, Pham Thi HM, Hoang Thi B, Chu QT, Lai Phuong PT, Do HN, Hoang Than HT, Ta Thi TT, Luu VH, Mai Duong PT, Thu Phung HT. Optimization of Microwave-Assisted Extraction Process of Callicarpa candicans (Burm. f.) Hochr Essential Oil and Its Inhibitory Properties against Some Bacteria and Cancer Cell Lines. (2020). LAPSE:2020.0317
Author Affiliations
Tran QT: Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet [ORCID]
Vu Thi TL: Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet
Do TL: Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet
Pham Thi HM: Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet
Hoang Thi B: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam
Chu QT: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam
Lai Phuong PT: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam
Do HN: Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet [ORCID]
Hoang Than HT: National Key Laboratory Petrochemical and Refinery Technologies, Vietnam Institute of Industrial Chemistry, Phuc Dien, Bac Tu Liem, Hanoi 10072, Vietnam
Ta Thi TT: Faculty of Biotechnology, Hanoi Open University, B101 Nguyen Hien, Hai Ba Trung, Hanoi 10072, Vietnam
Luu VH: Hanoi University of Natural Resources and Environment, Hanoi 10072, Vietnam
Mai Duong PT: Department of Chemistry, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea [ORCID]
Thu Phung HT: NTT Hi-tech Institute, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, ward 13, district 4, Ho Chi Minh City 700000, Vietnam
Vu Thi TL: Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet
Do TL: Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet
Pham Thi HM: Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet
Hoang Thi B: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam
Chu QT: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam
Lai Phuong PT: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam
Do HN: Vietnam Academy of Science and Technology, Graduate University of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay Dist., Hanoi 10072, Vietnam; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet [ORCID]
Hoang Than HT: National Key Laboratory Petrochemical and Refinery Technologies, Vietnam Institute of Industrial Chemistry, Phuc Dien, Bac Tu Liem, Hanoi 10072, Vietnam
Ta Thi TT: Faculty of Biotechnology, Hanoi Open University, B101 Nguyen Hien, Hai Ba Trung, Hanoi 10072, Vietnam
Luu VH: Hanoi University of Natural Resources and Environment, Hanoi 10072, Vietnam
Mai Duong PT: Department of Chemistry, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea [ORCID]
Thu Phung HT: NTT Hi-tech Institute, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, ward 13, district 4, Ho Chi Minh City 700000, Vietnam
Journal Name
Processes
Volume
8
Issue
2
Article Number
E173
Year
2020
Publication Date
2020-02-04
Published Version
ISSN
2227-9717
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PII: pr8020173, Publication Type: Journal Article
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LAPSE:2020.0317
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doi:10.3390/pr8020173
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[v1] (Original Submission)
Apr 1, 2020
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https://psecommunity.org/LAPSE:2020.0317
Original Submitter
Calvin Tsay
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