LAPSE:2020.0219
Published Article
LAPSE:2020.0219
Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
Ruth Muñoz-López, Eduardo Guzmán, Maria Mercedes Velázquez, Laura Fernández-Peña, María Dolores Merchán, Armando Maestro, Francisco Ortega, Ramón G. Rubio
February 12, 2020
Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two different effects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the effect of inhaled particles in the respiratory cycle.
Keywords
carbon nanosheets, dilational rheology, Langmuir monolayer, lipids, lung surfactant, particles, pollution, toxicity
Subject
Suggested Citation
Muñoz-López R, Guzmán E, Velázquez MM, Fernández-Peña L, Merchán MD, Maestro A, Ortega F, G. Rubio R. Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers. (2020). LAPSE:2020.0219
Author Affiliations
Muñoz-López R: Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid. Ciudad Universitaria s/n, 28040 Madrid, Spain
Guzmán E: Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid. Ciudad Universitaria s/n, 28040 Madrid, Spain; Instituto Pluridisciplinar, Universidad Complutense de Madrid. Paseo Juan XXIII, 1, 28040 Madrid, Spain [ORCID]
Velázquez MM: Departamento de Química Física, Facultad de Ciencias Químicas, Universidad de Salamanca. Plaza Caídos s/n, 37008 Salamanca, Spain [ORCID]
Fernández-Peña L: Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid. Ciudad Universitaria s/n, 28040 Madrid, Spain
Merchán MD: Departamento de Química Física, Facultad de Ciencias Químicas, Universidad de Salamanca. Plaza Caídos s/n, 37008 Salamanca, Spain [ORCID]
Maestro A: Institut Laue-Langevin. 71 Avenue des Martyrs, CS 20156, 38042 Grenoble, France
Ortega F: Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid. Ciudad Universitaria s/n, 28040 Madrid, Spain; Instituto Pluridisciplinar, Universidad Complutense de Madrid. Paseo Juan XXIII, 1, 28040 Madrid, Spain [ORCID]
G. Rubio R: Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid. Ciudad Universitaria s/n, 28040 Madrid, Spain; Instituto Pluridisciplinar, Universidad Complutense de Madrid. Paseo Juan XXIII, 1, 28040 Madrid, Spain
Journal Name
Processes
Volume
8
Issue
1
Article Number
E94
Year
2020
Publication Date
2020-01-10
Published Version
ISSN
2227-9717
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PII: pr8010094, Publication Type: Journal Article
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LAPSE:2020.0219
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doi:10.3390/pr8010094
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Feb 12, 2020
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CC BY 4.0
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Feb 12, 2020
 
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Calvin Tsay
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