High consumption of electricity represents an economic and social problem in warm places, caused by the massive use of cooling machines. Absorption systems are a sustainable method for air conditioning applications. However, environmental conditions should be analyzed to avoid crystallization problems of the working mixture. This article presents a thermal analysis of a solar absorption cooling system in dynamic conditions using NH₃-H₂O, H₂O-LiBr, NH₃-NaSCN, NH₃-LiNO₃, and H₂O-LiCl working mixtures using Equation Engineering Solver (EES) and TRaNsient SYstem Simulation (TRNSYS) software. A solar collector area of 42.5 m² was selected to carry out the thermal analysis. The results showed that H₂O-LiCl obtained the maximum solar (0.67) and minimum heating (0.33) fraction. However, it obtained the maximum lost heat fraction (0.12), in spite of obtaining the best coefficient of performance (COP) among the other working mixtures, due mainly to a crystallization problem. The gain fraction (GF) parameter was used to select the adequate solar collector number for each working mixture. NH₃-LiNO₃ and NH₃-H₂O obtained the highest GF (up 6), and both obtained the maximum solar (0.91) and minimum heating (0.09) fraction, respectively, using 88.8 and 100.4 m² of solar collector area, respectively.