Models involving decision variables in both discrete and continuous domain spaces are prevalent in process design. Generalized Disjunctive Programming (GDP) has emerged as a modeling framework to explicitly represent the relationship between algebraic descriptions and the logical structure of a design problem. However, fewer formulation examples exist for GDP compared to the traditional Mixed-Integer Nonlinear Programming (MINLP) modeling approach. In this paper, we propose the use of GDP as a modeling tool to organize model variants that arise due to characterization of different sections of an end-to-end process at different detail levels. We present an illustrative case study to demonstrate GDP usage for the generation of model variants catered to process synthesis integrated with purchasing and sales decisions in a techno-economic analysis. We also show how this GDP model can be used as part of a hierarchical decomposition scheme. These examples demonstrate how GDP can serve as a useful model abstraction layer for simplifying model development and upkeep, in addition to its traditional usage as a platform for advanced solution strategies.