Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

Jayasingh Anita Lett; Suresh Sagadevan; Joseph Joyce Prabhakar; Nor Aliya Hamizi; Irfan Anjum Badruddin; Mohd Rafie Johan; Ab Rahman Marlinda; Yasmin Abdul Wahab; Tatagar Mohammad Yunus Khan; Sarfaraz Kamangar

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2019.1624

Published Article

LAPSE:2019.1624

Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

Jayasingh Anita Lett, Suresh Sagadevan, Joseph Joyce Prabhakar, Nor Aliya Hamizi, Irfan Anjum Badruddin, Mohd Rafie Johan, Ab Rahman Marlinda, Yasmin Abdul Wahab, Tatagar Mohammad Yunus Khan, Sarfaraz Kamangar

December 16, 2019

Infections after bone reconstructive surgery become an authentic therapeutic and economic issue when it comes to a modern health care system. In general; infected bone defects are regarded as contraindications for bone grafting. Since the pathogens develop a biofilm on the inner surface of the bone; local delivery of antibiotics becomes more important. The present work focuses on the synthesis of Mesoporous Hydroxyapatite (MPHAP) loaded with drug Vancomycin (Van) and to investigate its loading and leaching ability in phosphate buffer solution (PBS), to be used for post-operative infections. The effect of pore size on MPHAP was analyzed using different fatty acids as organic modifiers. The impacts of various fatty acids chain length on the morphology and pore size were studied. A simple impregnation technique with optimized conditions ensured a high antibiotic loading (up to 0.476 + 0.0135 mg/mL), with a complete in vitro release obtained within 50 h.

Record ID

LAPSE:2019.1624

Keywords

drug delivery, fatty acid, Hydroxyapatite, Sol-Gel synthesis, Vancomycin

Subject

Biosystems

Suggested Citation

Lett JA, Sagadevan S, Prabhakar JJ, Hamizi NA, Badruddin IA, Johan MR, Marlinda AR, Abdul Wahab Y, Yunus Khan TM, Kamangar S. Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes. (2019). LAPSE:2019.1624

Author Affiliations

Lett JA: Department of Physics, Sathyabama Institute of Science and Technology, Chennai-600 119, Tamil Nadu, India
Sagadevan S: Nanotechnology & Catalysis Research Centre, University of Malaya, Kuala Lumpur 50603, Malaysia
Prabhakar JJ: Department of General Surgery, Madras Medical College, Chennai-600003, India
Hamizi NA: Nanotechnology & Catalysis Research Centre, University of Malaya, Kuala Lumpur 50603, Malaysia
Badruddin IA: Department of Mechanical Engineering, College of Engineering, King Khalid University, PO Box 394, Abha 61421, Saudi Arabia [ORCID]
Johan MR: Nanotechnology & Catalysis Research Centre, University of Malaya, Kuala Lumpur 50603, Malaysia
Marlinda AR: Nanotechnology & Catalysis Research Centre, University of Malaya, Kuala Lumpur 50603, Malaysia
Abdul Wahab Y: Nanotechnology & Catalysis Research Centre, University of Malaya, Kuala Lumpur 50603, Malaysia [ORCID]
Yunus Khan TM: Department of Mechanical Engineering, College of Engineering, King Khalid University, PO Box 394, Abha 61421, Saudi Arabia
Kamangar S: Department of Mechanical Engineering, College of Engineering, King Khalid University, PO Box 394, Abha 61421, Saudi Arabia

Journal Name

Processes

Volume

7

Issue

11

Article Number

E826

Year

2019

Publication Date

2019-11-07