The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

Ngoc-Tram Nguyen-Thi; Linh Phuong Pham Tran; Ngoc Thuy Trang Le; Minh-Tri Cao; The-Nam Tran; Ngoc Tung Nguyen; Cong Hao Nguyen; Dai-Hai Nguyen; Van Thai Than; Quang Tri Le; Nguyen Quang Trung

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2019.1608

Published Article

LAPSE:2019.1608

The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

Ngoc-Tram Nguyen-Thi, Linh Phuong Pham Tran, Ngoc Thuy Trang Le, Minh-Tri Cao, The-Nam Tran, Ngoc Tung Nguyen, Cong Hao Nguyen, Dai-Hai Nguyen, Van Thai Than, Quang Tri Le, Nguyen Quang Trung

December 16, 2019

As a promising candidate for expanding the capacity of drug loading in silica nanoplatforms, hollow mesoporous silica nanoparticles (HMSNs) are gaining increasing attention. In this study, porous nanosilica (PNS) and HMSNs were prepared by the sol-gel method and template assisted method, then further used for Rhodamine (RhB) loading. To characterize the as-synthesized nanocarriers, a number of techniques, including X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption-desorption isotherms, dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR) were employed. The size of HMSN nanoparticles in aqueous solution averaged 134.0 ± 0.3 nm, which could be adjusted by minor changes during synthesis, whereas that of PNS nanoparticles was 63.4 ± 0.6 nm. In addition, the encapsulation of RhB into HMSN nanoparticles to form RhB-loaded nanocarriers (RhB/HMSN) was successful, achieving high loading efficiency (51.67% ± 0.11%). This was significantly higher than that of RhB-loaded PNS (RhB/PNS) (12.24% ± 0.24%). Similarly, RhB/HMSN also possessed a higher RhB loading content (10.44% ± 0.02%) compared to RhB/PNS (2.90% ± 0.05%). From those results, it is suggested that prepared HMSN nanocarriers may act as high-capacity carriers in drug delivery applications.

Record ID

LAPSE:2019.1608

Keywords

drug delivery system, high drug loading capacity, hollow mesoporous silica, nanoparticles, porous silica

Subject

Materials

Suggested Citation

Nguyen-Thi NT, Pham Tran LP, Le NTT, Cao MT, Tran TN, Nguyen NT, Nguyen CH, Nguyen DH, Than VT, Le QT, Trung NQ. The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity. (2019). LAPSE:2019.1608

Author Affiliations

Nguyen-Thi NT: Tra Vinh University, No. 126, Nguyen Thien Thanh, Ward 5, Tra Vinh city 940000, Vietnam; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam
Pham Tran LP: Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam
Le NTT: Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam [ORCID]
Cao MT: Tra Vinh University, No. 126, Nguyen Thien Thanh, Ward 5, Tra Vinh city 940000, Vietnam
Tran TN: Tra Vinh University, No. 126, Nguyen Thien Thanh, Ward 5, Tra Vinh city 940000, Vietnam
Nguyen NT: Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam; Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam [ORCID]
Nguyen CH: Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam
Nguyen DH: Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Vietnam
Than VT: NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam; Center of Excellence for Functional Polymers and NanoEngineering, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam [ORCID]
Le QT: Department of Orthopedic, 7A Military Hospital, 466 Nguyen Trai Street, Ward 8, District 5, 72706, Ho Chi Minh City 700000, Vietnam
Trung NQ: Nghe An Oncology Hospital, Vinh City 460000, Vietnam [ORCID]

Journal Name

Processes

Volume

7

Issue

11

Article Number

E805

Year

2019

Publication Date

2019-11-04