LAPSE:2019.1570
Published Article
LAPSE:2019.1570
Taste Masking of Nizatidine Using Ion-Exchange Resins
Pattaraporn Panraksa, Kasidech Boonsermsukcharoen, Kyu-Mok Hwang, Eun-Seok Park, Pensak Jantrawut
December 11, 2019
The purpose of this study was to mask the bitter taste of nizatidine (NZD) using cation-exchange resins. Amberlite IRP-69 and Dowex-50 containing cross-linked polystyrene backbones were used. The drug resin complexes were prepared by batch process using drug: resin ratios of 1:1, 1:3, and 1:5. The optimum drug: resin ratio and the time required for maximum percentage drug loading into the complexes were determined. The selected drug-resin complexes were evaluated for morphology, drug release, and taste. The NZD-Dowex complex was obtained at a drug: resin ratio of 1:5 using a stirring time of 1 h in order to get 100% loading of NZD. The NZD-Dowex complex had a spherical shape and smooth texture similar to Dowex resin. The NZD-Dowex complex with a ratio of 1:5 showed that in vitro drug release of 4.27% at 5 min in simulated salivary fluid of pH 6.8 and 99.67% at 1 h in simulated gastric fluid of pH 1.2. NZD’s bitter taste was effectively masked when it formed a complex with Dowex at a ratio of 1:5. This was proved by an electronic tongue and human test panel.
Keywords
Amberlite, Dowex, electronic tongue, ion-exchange resins, nizatidine
Subject
Suggested Citation
Panraksa P, Boonsermsukcharoen K, Hwang KM, Park ES, Jantrawut P. Taste Masking of Nizatidine Using Ion-Exchange Resins. (2019). LAPSE:2019.1570
Author Affiliations
Panraksa P: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand [ORCID]
Boonsermsukcharoen K: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
Hwang KM: School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
Park ES: School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
Jantrawut P: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand; Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 502 [ORCID]
Journal Name
Processes
Volume
7
Issue
11
Article Number
E779
Year
2019
Publication Date
2019-10-30
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr7110779, Publication Type: Journal Article
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LAPSE:2019.1570
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doi:10.3390/pr7110779
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Dec 11, 2019
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CC BY 4.0
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Dec 11, 2019
 
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Original Submitter
Calvin Tsay
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