LAPSE:2019.1284
Published Article
LAPSE:2019.1284
Practical Solutions for Specific Growth Rate Control Systems in Industrial Bioreactors
Vytautas Galvanauskas, Rimvydas Simutis, Donatas Levišauskas, Renaldas Urniežius
December 9, 2019
This contribution discusses the main challenges related to successful application of automatic control systems used to control specific growth rate in industrial biotechnological processes. It is emphasized that, after the implementation of basic automatic control systems, primary attention shall be paid to the specific growth rate control systems because this process variable critically affects the physiological state of microbial cultures and the formation of the desired product. Therefore, control of the specific growth rate enables improvement of the quality and reproducibility of the biotechnological processes. The main requirements have been formulated that shall be met to successfully implement the specific growth rate control systems in industrial bioreactors. The relatively easy-to-implement schemes of specific growth rate control systems have been reviewed and discussed. The recommendations for selection of particular control systems for specific biotechnological processes have been provided.
Keywords
batch-to-batch reproducibility, bioreactor control, biotechnological processes, specific growth rate control
Suggested Citation
Galvanauskas V, Simutis R, Levišauskas D, Urniežius R. Practical Solutions for Specific Growth Rate Control Systems in Industrial Bioreactors. (2019). LAPSE:2019.1284
Author Affiliations
Galvanauskas V: Department of Automation, Kaunas University of Technology, 51367 Kaunas, Lithuania
Simutis R: Department of Automation, Kaunas University of Technology, 51367 Kaunas, Lithuania
Levišauskas D: Department of Automation, Kaunas University of Technology, 51367 Kaunas, Lithuania
Urniežius R: Department of Automation, Kaunas University of Technology, 51367 Kaunas, Lithuania
Journal Name
Processes
Volume
7
Issue
10
Article Number
E693
Year
2019
Publication Date
2019-10-02
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr7100693, Publication Type: Review
Record Map
Published Article

LAPSE:2019.1284
This Record
External Link

doi:10.3390/pr7100693
Publisher Version
Download
Files
[Download 1v1.pdf] (1.6 MB)
Dec 9, 2019
Main Article
License
CC BY 4.0
Meta
Record Statistics
Record Views
433
Version History
[v1] (Original Submission)
Dec 9, 2019
 
Verified by curator on
Dec 9, 2019
This Version Number
v1
Citations
Most Recent
This Version
URL Here
https://psecommunity.org/LAPSE:2019.1284
 
Original Submitter
Calvin Tsay
Links to Related Works
Directly Related to This Work
Publisher Version