LAPSE:2019.1204
Published Article
LAPSE:2019.1204
Explicit Residence Time Distribution of a Generalised Cascade of Continuous Stirred Tank Reactors for a Description of Short Recirculation Time (Bypassing)
Peter Toson, Pankaj Doshi, Dalibor Jajcevic
November 24, 2019
The tanks-in-series model (TIS) is a popular model to describe the residence time distribution (RTD) of non-ideal continuously stirred tank reactors (CSTRs) with limited back-mixing. In this work, the TIS model was generalised to a cascade of n CSTRs with non-integer non-negative n. The resulting model describes non-ideal back-mixing with n > 1. However, the most interesting feature of the n-CSTR model is the ability to describe short recirculation times (bypassing) with n < 1 without the need of complex reactor networks. The n-CSTR model is the only model that connects the three fundamental RTDs occurring in reactor modelling by variation of a single shape parameter n: The unit impulse at nā†’0, the exponential RTD of an ideal CSTR at n = 1, and the delayed impulse of an ideal plug flow reactor at nā†’āˆž. The n-CSTR model can be used as a stand-alone model or as part of a reactor network. The bypassing material fraction for the regime n < 1 was analysed. Finally, a Fourier analysis of the n-CSTR was performed to predict the ability of a unit operation to filter out upstream fluctuations and to model the response to upstream set point changes.
Keywords
bypassing, continuous manufacturing, continuous stirred tank reactor, Fourier analysis, residence time distribution
Suggested Citation
Toson P, Doshi P, Jajcevic D. Explicit Residence Time Distribution of a Generalised Cascade of Continuous Stirred Tank Reactors for a Description of Short Recirculation Time (Bypassing). (2019). LAPSE:2019.1204
Author Affiliations
Toson P: Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria [ORCID]
Doshi P: Worldwide Research and Development, Pfizer Inc. Groton, CT 06340, USA
Jajcevic D: Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria
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Journal Name
Processes
Volume
7
Issue
9
Article Number
E615
Year
2019
Publication Date
2019-09-10
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr7090615, Publication Type: Journal Article
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LAPSE:2019.1204
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doi:10.3390/pr7090615
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Nov 24, 2019
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CC BY 4.0
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Nov 24, 2019
 
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Nov 24, 2019
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Original Submitter
Calvin Tsay
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