LAPSE:2019.1083
Published Article
LAPSE:2019.1083
On the Three-Dimensional Structure of the Flow through Deterministic Lateral Displacement Devices and Its Effects on Particle Separation
Valentina Biagioni, Alessandra Adrover, Stefano Cerbelli
October 26, 2019
Experiments have shown that a suspension of particles of different dimensions pushed through a periodic lattice of micrometric obstacles can be sorted based on particle size. This label-free separation mechanism, referred to as Deterministic Lateral Displacement (DLD), has been explained hinging on the structure of the 2D solution of the Stokes flow through the patterned geometry, thus neglecting the influence of the no-slip conditions at the top and bottom walls of the channel hosting the obstacle lattice. We show that the no-slip conditions at these surfaces trigger the onset of off-plane velocity components, which impart full three-dimensional character to the flow. The impact of the 3D flow structure on particle transport is investigated by enforcing an excluded volume approach for modelling the interaction between the finite-sized particles and the solid surfaces. We find that the combined action of particle diffusion and of the off-plane velocity component causes the suspended particles to migrate towards the top and bottom walls of the channel. Preliminary results suggest that this effect makes the migration angle of the particles significantly different from that obtained by assuming a strictly two-dimensional structure for the flow of the suspending fluid.
Keywords
deterministic ratchets, label-free separation, three-dimensional effects
Subject
Suggested Citation
Biagioni V, Adrover A, Cerbelli S. On the Three-Dimensional Structure of the Flow through Deterministic Lateral Displacement Devices and Its Effects on Particle Separation. (2019). LAPSE:2019.1083
Author Affiliations
Biagioni V: Dipartimento di Ingegneria Chimica Materiali Ambiente, Sapienza Università di Roma, via Eudossiana 18, 00184 Roma, Italy
Adrover A: Dipartimento di Ingegneria Chimica Materiali Ambiente, Sapienza Università di Roma, via Eudossiana 18, 00184 Roma, Italy [ORCID]
Cerbelli S: Dipartimento di Ingegneria Chimica Materiali Ambiente, Sapienza Università di Roma, via Eudossiana 18, 00184 Roma, Italy
[Login] to see author email addresses.
Journal Name
Processes
Volume
7
Issue
8
Article Number
E498
Year
2019
Publication Date
2019-08-01
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr7080498, Publication Type: Journal Article
Record Map
Published Article

LAPSE:2019.1083
This Record
External Link

doi:10.3390/pr7080498
Publisher Version
Download
Files
[Download 1v1.pdf] (22.1 MB)
Oct 26, 2019
Main Article
License
CC BY 4.0
Meta
Record Statistics
Record Views
442
Version History
[v1] (Original Submission)
Oct 26, 2019
 
Verified by curator on
Oct 26, 2019
This Version Number
v1
Citations
Most Recent
This Version
URL Here
https://psecommunity.org/LAPSE:2019.1083
 
Original Submitter
Calvin Tsay
Links to Related Works
Directly Related to This Work
Publisher Version