LAPSE:2019.0870
Published Article
LAPSE:2019.0870
Injectable Chitosan Scaffolds with Calcium β-Glycerophosphate as the Only Neutralizing Agent
July 31, 2019
The presented work describes the method of preparation of thermosensitive chitosan hydrogels using calcium β-glycerophosphate salt as the only pH neutralizing agent and supporting the crosslinking process. The presence of calcium ions instead of sodium ions is particularly important in the case of scaffolds in bone tissue engineering. Rheological and physicochemical properties of low concentrated chitosan solutions with the addition of calcium β-glycerophosphate were investigated using rotational rheometry techniques, Zeta potential (by electrophoresis), XPS, and SEM analysis together with an EDS detector. It was found to be possible to prepare colloidal solutions of chitosan containing only calcium β-glycerophosphate (without sodium ions) undergoing a sol-gel phase transition at the physiological temperature of the human body. It has also been shown that it is possible to further enrich the obtained cellular scaffolds with calcium ions. Using the addition of calcium carbonate, hydrogels with a physiological ratio of calcium to phosphorus (1.6−1.8):1 were obtained.
Keywords
bone tissue engineering, calcium β-glycerophosphate, chitosan, injectable scaffolds, rheology, sol-gel phase transitions
Subject
Suggested Citation
Owczarz P, Rył A, Dziubiński M, Sielski J. Injectable Chitosan Scaffolds with Calcium β-Glycerophosphate as the Only Neutralizing Agent. (2019). LAPSE:2019.0870
Author Affiliations
Owczarz P: Department of Chemical Engineering, Lodz University of Technology, 90-924 Lodz, Poland [ORCID]
Rył A: Department of Chemical Engineering, Lodz University of Technology, 90-924 Lodz, Poland
Dziubiński M: Department of Chemical Engineering, Lodz University of Technology, 90-924 Lodz, Poland [ORCID]
Sielski J: Department of Molecular Engineering, Lodz University of Technology, 90-924 Lodz, Poland [ORCID]
[Login] to see author email addresses.
Journal Name
Processes
Volume
7
Issue
5
Article Number
E297
Year
2019
Publication Date
2019-05-19
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr7050297, Publication Type: Journal Article
Record Map
Published Article

LAPSE:2019.0870
This Record
External Link

doi:10.3390/pr7050297
Publisher Version
Download
Files
[Download 1v1.pdf] (3.3 MB)
Jul 31, 2019
Main Article
License
CC BY 4.0
Meta
Record Statistics
Record Views
583
Version History
[v1] (Original Submission)
Jul 31, 2019
 
Verified by curator on
Jul 31, 2019
This Version Number
v1
Citations
Most Recent
This Version
URL Here
https://psecommunity.org/LAPSE:2019.0870
 
Original Submitter
Calvin Tsay
Links to Related Works
Directly Related to This Work
Publisher Version