This paper presents a methodology for power consumption estimation considering harmonic and interharmonic content and then it is compared to the power consumption estimation commonly done by commercial equipment based on the fundamental frequency, and how they can underestimate the power consumption considering power quality disturbances (PQD). For this purpose, data of electrical activity at the electrical distribution boards in a healthcare facility is acquired for a long time period with proprietary equipment. An analysis in the acquired current and voltage signals is done, in order to compare the power consumption centered in the fundamental frequency with the generalized definition of power consumption. The results obtained from the comparison in the power consumption estimation show differences between 4% and 10% of underestimated power consumption. Thus, it is demonstrated that the presence of harmonic and interharmonic content provokes a significant underestimation of power consumption using only the power consumption centered at the fundamental frequency.