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LAPSE:2019.0580
Published Article
LAPSE:2019.0580
Evaluation of Conditions Affecting Properties of Gac (Momordica Cocochinensis Spreng) Oil-Loaded Solid Lipid Nanoparticles (SLNs) Synthesized Using High-Speed Homogenization Process
Huynh Cang Mai, Thai Sa Vin Nguyen, Thi Hong Nhan Le, Duy Chinh Nguyen, Long Giang Bach
June 10, 2019
In this study, we attempted the preparation of gac oil-loaded solid lipid nanoparticles (SLNs) by the high-speed homogenization method using Naterol SE solid lipid, a cosmetic self-emulsifying base, and surfactant and investigated the effects of different conditions on the characteristics of the resulting nanoparticles. The suspensions containing 5% active agents (gac-oil, w/w) were dispersed in a surfactant concentration of 5% (w/w) (Span 80:Tween 80 ratio of 28:72 w/w) and 2.5% (w/w) of solid lipid (Naterol SE) concentration. Suitable conditions for hot homogenization were 13,000 rpm, 60 min and 60 °C for speed, time and temperature, respectively. The suitable conditions for the subsequent cold homogenization were 25 min of homogenization time and 5 °C of temperature. The results showed that the mean size of SLNs-gac oil was 107 nm (measured by laser diffraction spectrometry, LDS), and dried size of SLNs-gac oil ranged from 50 to 80 nm (measured by transmission electron microscope, TEM). In addition, the study investigated the impact of gac oil content on the particle size of SLNs-gac oil and its stability under different storage conditions of UV radiation and storage temperature. At high storage temperatures, the color changes (ΔE) of the samples were more profound in comparison to that at the low storage temperature. The ΔE value of the blank sample (SLN-FREE gac-oil) was higher than that of the Gac oil-loaded SLNs samples (SLN-gac oil).
Keywords
carotenoids, cold homogenization, gac oil, hot homogenization, Momordica cocochinensis Spreng, Naterol SE, Solid lipid nanoparticles (SLNs)
Subject
Suggested Citation
Mai HC, Nguyen TSV, Le THN, Nguyen DC, Bach LG. Evaluation of Conditions Affecting Properties of Gac (Momordica Cocochinensis Spreng) Oil-Loaded Solid Lipid Nanoparticles (SLNs) Synthesized Using High-Speed Homogenization Process. (2019). LAPSE:2019.0580
Author Affiliations
Mai HC: Department of Chemical Engineering and Processing, Nong Lam University, Ho Chi Minh City 700000, Vietnam
Nguyen TSV: Department of Chemical Engineering and Processing, Nong Lam University, Ho Chi Minh City 700000, Vietnam
Le THN: Department of Chemical Engineering, HCMC University of Technology, VNU-HCM, Ho Chi Minh City 700000, Vietnam
Nguyen DC: NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam [ORCID]
Bach LG: NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam; Center of Excellence for Biochemistry and Natural Products, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
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Journal Name
Processes
Volume
7
Issue
2
Article Number
E90
Year
2019
Publication Date
2019-02-12
Published Version
ISSN
2227-9717
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PII: pr7020090, Publication Type: Journal Article
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LAPSE:2019.0580
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doi:10.3390/pr7020090
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Jun 10, 2019
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