In Southwest China large-scale hydropower projects, the hydraulic conductivity and fracture aperture within the rock mass of a reservoir bank slope has dramatically undergone a time series of evolution during dam abutment excavation, reservoir impounding and fluctuation operation, and discharge atomization. Accordingly, seepage control measures by hydro-structures such as drainage or water insulation curtains should be guided by scientific foundation with a dynamic process covering life-cycle performance. In this paper, the up-to-date status of studying the evolution mechanism of seepage characteristics relating to fractured rock hydraulics from experimental samples to the engineering scale of the rock mass is reviewed for the first time. Then, the experimental findings and improved practice method on nonlinear seepage flow under intensive pressure drives are introduced. Finally, the scientific progress made in fractured rock seepage control theory and optimization of the design technology of high-steep slope engineering is outlined. The undertaken studies summarized herewith are expected to contribute to laying a foundation to guide the further development of effective geophysical means and integrated monitoring systems in hydropower station construction fields.