LAPSE:2019.0507
Published Article
LAPSE:2019.0507
Early Afterdepolarisations Induced by an Enhancement in the Calcium Current
April 15, 2019
Excitable biological cells, such as cardiac muscle cells, can exhibit complex patterns of oscillations such as spiking and bursting. Moreover, it is well known that an enhancement in calcium currents may yield certain kind of cardiac arrhythmia, so-called early afterdepolarisations (EADs). The presence of EADs strongly correlates with the onset of dangerous cardiac arrhythmia. In this paper we study mathematically and numerically the dynamics of a cardiac muscle cell with respect to the calcium current by investigating a simplistic system of differential equations. For the study of this phenomena, we use bifurcation theory, numerical bifurcation analysis, geometric singular perturbation theory and computational methods to investigate a nonlinear multiple time scales system. It will turn out that EADs related to an enhanced calcium current are canard⁻induced and that we have to combine these theories to derive a better understanding of the dynamics behind EADs. Moreover, a suitable time scale separation argument determines the important and sensitive system parameters which are related to the occurrence of EADs.
Keywords
bifurcation analysis, calcium current, canard-induced EADs, geometric singular perturbation theory, multiple time scales, nonlinear dynamics
Subject
Suggested Citation
Erhardt AH. Early Afterdepolarisations Induced by an Enhancement in the Calcium Current. (2019). LAPSE:2019.0507
Author Affiliations
Erhardt AH: Department of Mathematics, University of Oslo, P.O. Box 1053 Blindern, 0316 Oslo, Norway [ORCID]
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Journal Name
Processes
Volume
7
Issue
1
Article Number
E20
Year
2019
Publication Date
2019-01-04
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr7010020, Publication Type: Journal Article
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LAPSE:2019.0507
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doi:10.3390/pr7010020
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Apr 15, 2019
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CC BY 4.0
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[v1] (Original Submission)
Apr 15, 2019
 
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Apr 15, 2019
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Original Submitter
Calvin Tsay
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