LAPSE:2019.0471
Published Article
LAPSE:2019.0471
Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part I: Conceptual Process Design and Cost Estimation
Maximilian Sixt, Axel Schmidt, Fabian Mestmäcker, Maximilian Johannes Huter, Lukas Uhlenbrock, Jochen Strube
April 8, 2019
The article summarizes a systematic process design for the extraction and purification of artemisinin from annual mugwort (Artemisia annua L.). Artemisinin serves as an anti-malaria drug, therefore, resource-efficient and economic processes for its production are needed. The process design was based on lab-scale experiments and afterwards piloted on miniplant-scale at the institute. In this part of the article, a detailed economic feasibility studies including a reference process as a benchmark the lab-scale process and the pilot-scale process is given. Relevant differences between the different scales are discussed. The details of the respective unit operations (solid-liquid extraction, liquid-liquid extraction, chromatography and crystallization) are presented in dedicated articles. The study showed that even miniaturized lab-scale experiments are able to deliver data detailed enough for scale-up calculations on a theoretical basis. To our knowledge, a comparable systematic process design and piloting was never performed by academia before.
Keywords
artemisinin, cost estimation, miniplant, piloting, process design
Suggested Citation
Sixt M, Schmidt A, Mestmäcker F, Huter MJ, Uhlenbrock L, Strube J. Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part I: Conceptual Process Design and Cost Estimation. (2019). LAPSE:2019.0471
Author Affiliations
Sixt M: Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
Schmidt A: Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany [ORCID]
Mestmäcker F: Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
Huter MJ: Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
Uhlenbrock L: Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
Strube J: Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
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Journal Name
Processes
Volume
6
Issue
9
Article Number
E161
Year
2018
Publication Date
2018-09-07
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr6090161, Publication Type: Journal Article
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LAPSE:2019.0471
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doi:10.3390/pr6090161
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Apr 8, 2019
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CC BY 4.0
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[v1] (Original Submission)
Apr 8, 2019
 
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Apr 8, 2019
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Original Submitter
Calvin Tsay
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