To reduce CO 2 emissions from power plants, electricity companies have diversified their generation sources. Fossil fuels, however, still remain an integral energy generation source as they are more reliable compared to the renewable energy sources. This diversification as well as changing electricity demand could hinder effective economical operation of an amine-based post-combustion CO 2 capture (PCC) plant attached to the power plant to reduce CO 2 emissions. This is as a result of large fluctuations in the flue gas flow rate and unavailability of steam from the power plant. To tackle this problem, efficient control algorithms are necessary. In this work, tracking and economic model predictive controllers are applied to a PCC plant and their economic performance is compared under different scenarios. The results show that economic model predictive control has a potential to improve the economic performance and energy efficiency of the amine-based PCC process up to 6% and 7%, respectively, over conventional model predictive control.