Accelerator Driven Systems (ADS) seem to be a good solution for safe nuclear waste transmutation. One of the most important challenges for this kind of machine is the target design, particularly for what concerning the target cooling system. In order to optimize this component a CFD-based approach has been chosen. After the definition of a reference design (Be target cooled by He), some parameters have been varied in order to optimize the thermal-fluid-dynamic features. The final optimized target design has an increased security margin for what regarding Be melting and reduces the maximum coolant velocity (and consequently even more the pressure drops).