Steam methane reforming (SMR) is the most common commercial method of industrial hydrogen production. Control of the catalyst tube temperature is a fundamental demand of the reformer design because the tube temperature must be maintained within a range that the catalysts have high activity and the tube has minor damage. In this paper, the transport and chemical reaction in an industrial-scale steam methane reformer are simulated using computational fluid dynamics (CFD). Two factors influencing the reformer temperature, hydrogen yield and stress distribution are discussed: (1) the mole fraction of steam (YH2O) and (2) the inlet velocity of the reforming reactants. The purpose of this paper is to get a better understanding of the flow and thermal development in a reformer and thus, to make it possible to improve the performance and lifetime of a steam reformer. It is found that the lowest temperature at the reforming tube surface occurs when YH2O is 0.5. Hydrogen yield has the highest value when YH2O is 0.5. The wall shear stress at the reforming tube surface is higher at a higher YH2O. The surface temperature of a reforming tube increases with the inlet velocity of the reforming reactants. Finally, the wall shear stress at the reforming tube surface increases with the inlet velocity of the reforming reactants.