Recent innovations in engine control and diagnostics are providing room for development of innovative combustion approaches (e.g., low-temperature combustion) able to minimize the creation of pollutants. To ensure the constant fulfillment of the prescribed thermodynamic conditions, however, a fast real-time monitoring of the in-cylinder pressure is needed. To this end, dynamic pressure sensors, flush-mounted on the cylinder head, are commonly used. With this approach, the measurement accuracy is high, but the durability is limited by the harsh working conditions. The installation on the cylinder head is also complex. The development of robust and effective indirect measurement systems could then represent the enabler of a further development of this technology. In the present study, an innovative methodology to measure the in-cylinder pressure has been conceived and extensively tested on a four-stroke single-cylinder engine. The proposed approach is based on the analysis of the mechanical stress on the engine studs by means of a piezoelectric strain washer. This solution allows the user for a rapid and cost-effective sensor installation, described in the paper along with the signal post-processing techniques. Results showed good accuracy and robustness of the methodology, making the results of practical use for engine control.