LAPSE:2018.0292
Published Article
LAPSE:2018.0292
Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.
Maximilian Sixt, Jochen Strube
July 31, 2018
In this study, the solvent based extraction of artemisinin from Artemisia annua L. using acetone in percolation mode is compared to the method of pressurized hot water extraction. Both techniques are simulated by a physico-chemical process model. The model as well as the model parameter determination, including the thermal degradation of artemisinin are shown and discussed. For the conventional extraction, a solvent screening is performed considering various organic solvents. A temperature screening is presented for the systematic design of the pressurized hot water extraction. The best temperature with regards to thermal decomposition and high productivity was found to be 80 °C. Both, conventional percolation and Pressurized Hot Water Extraction (PHWE) are suitable for the extraction of artemisinin. The extraction curves show a high conformity with the simulation results.
Keywords
artemisinin, Extraction, Green Solvents, Modelling, Pressurized Hot Water Extraction, Simulation
Suggested Citation
Sixt M, Strube J. Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.. (2018). LAPSE:2018.0292
Author Affiliations
Sixt M: Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
Strube J: Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
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Journal Name
Processes
Volume
5
Issue
4
Article Number
E86
Year
2017
Publication Date
2017-12-20
Published Version
ISSN
2227-9717
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PII: pr5040086, Publication Type: Journal Article
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LAPSE:2018.0292
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doi:10.3390/pr5040086
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Jul 31, 2018
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