LAPSE:2018.0254
Published Article
LAPSE:2018.0254
Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer
July 31, 2018
Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers.
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Keywords
anticancer, breast cancer, Group 4 metallocene polymers, Group 4 metallocenes, interfacial polycondensation, organotin polyethers, pancreatic cancer, poly(ethylene glycol), prostate cancer
Subject
Suggested Citation
Carraher CE, Roner MR, Frank J, Moric-Johnson A, Miller LC, Black K, Slawek P, Mosca F, Einkauf JD, Russell F. Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer. (2018). LAPSE:2018.0254
Author Affiliations
Carraher CE: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Roner MR: Department of Biology, University of Texas Arlington, Arlington, TX 76010, USA
Frank J: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Moric-Johnson A: Department of Biology, University of Texas Arlington, Arlington, TX 76010, USA
Miller LC: Department of Biology, University of Texas Arlington, Arlington, TX 76010, USA
Black K: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Slawek P: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Mosca F: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Einkauf JD: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Russell F: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
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Roner MR: Department of Biology, University of Texas Arlington, Arlington, TX 76010, USA
Frank J: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Moric-Johnson A: Department of Biology, University of Texas Arlington, Arlington, TX 76010, USA
Miller LC: Department of Biology, University of Texas Arlington, Arlington, TX 76010, USA
Black K: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Slawek P: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Mosca F: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Einkauf JD: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
Russell F: Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
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Journal Name
Processes
Volume
5
Issue
3
Article Number
E50
Year
2017
Publication Date
2017-09-01
Published Version
ISSN
2227-9717
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Original Submission
Other Meta
PII: pr5030050, Publication Type: Review
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Published Article
LAPSE:2018.0254
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doi:10.3390/pr5030050
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[v1] (Original Submission)
Jul 31, 2018
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Jul 31, 2018
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