LAPSE:2018.0224
Published Article
LAPSE:2018.0224
Biodegradable and Biocompatible PDLLA-PEG1k-PDLLA Diacrylate Macromers: Synthesis, Characterisation and Preparation of Soluble Hyperbranched Polymers and Crosslinked Hydrogels
Alan Hughes, Hongyun Tai, Anna Tochwin, Wenxin Wang
July 31, 2018
A series of PDLLA-PEG1k-PDLLA tri-block co-polymers with various compositions, i.e., containing 2⁻10 lactoyl units, were prepared via ring opening polymerisation of d,l-lactide in the presence of poly (ethylene glycol) (PEG) (Mn = 1000 g·mol−1) as the initiator and stannous 2-ethylhexanoate as the catalyst at different feed ratios. PDLLA-PEG1k-PDLLA co-polymers were then functionalised with acrylate groups using acryloyl chloride under various reaction conditions. The diacrylated PDLLA-PEG1k-PDLLA (diacryl-PDLLA-PEG1k-PDLLA) were further polymerised to synthesize soluble hyperbranched polymers by either homo-polymerisation or co-polymerisation with poly(ethylene glycol) methyl ether methylacrylate (PEGMEMA) via free radical polymerisation. The polymer samples obtained were characterised by ¹H NMR (proton Nuclear Magnetic Resonance), FTIR (Fourier Transform Infra-red spectroscopy), and GPC (Gel Permeation Chromatography). Moreover, the diacryl-PDLLA-PEG1k-PDLLA macromers were used for the preparation of biodegradable crosslinked hydrogels through the Michael addition reaction and radical photo-polymerisation with or without poly(ethylene glycol) methyl ether methylacrylate (PEGMEMA, Mn = 475 g·mol−1) as the co-monomer. It was found that fine tuning of the diacryl-PDLLA-PEG1k-PDLLA constituents and its combination with co-monomers resulted in hydrogels with tailored swelling properties. It is envisioned that soluble hyperbranched polymers and crosslinked hydrogels prepared from diacryl-PDLLA-PEG1k-PDLLA macromers can have promising applications in the fields of nano-medicines and regenerative medicines.
Keywords
">d,, ">l-lactide, biodegradable hydrogels, hyperbranched polymers, macromers, poly (ethylene glycol), triblock co-polymers
Subject
Suggested Citation
Hughes A, Tai H, Tochwin A, Wang W. Biodegradable and Biocompatible PDLLA-PEG1k-PDLLA Diacrylate Macromers: Synthesis, Characterisation and Preparation of Soluble Hyperbranched Polymers and Crosslinked Hydrogels. (2018). LAPSE:2018.0224
Author Affiliations
Hughes A: School of Chemistry, Bangor University, Deiniol Road, Bangor, Gwynedd LL57 2UW, UK
Tai H: School of Chemistry, Bangor University, Deiniol Road, Bangor, Gwynedd LL57 2UW, UK [ORCID]
Tochwin A: School of Chemistry, Bangor University, Deiniol Road, Bangor, Gwynedd LL57 2UW, UK
Wang W: Charles Institute of Dermatology, University College Dublin, Dublin 4, Ireland [ORCID]
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Journal Name
Processes
Volume
5
Issue
2
Article Number
E18
Year
2017
Publication Date
2017-04-20
Published Version
ISSN
2227-9717
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PII: pr5020018, Publication Type: Journal Article
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LAPSE:2018.0224
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doi:10.3390/pr5020018
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Jul 31, 2018
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